Prazosin hydrochloride
| Code | Size | Price |
|---|
| TAR-T1050-1mL | 1 mL * 10 mM (in DMSO) | £111.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T1050-100mg | 100mg | £111.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Prazosin Hydrochloride reduces peripheral resistance and relaxes vascular smooth muscles as a selective adrenergic alpha-1 antagonist by a mechanism not completely known. Prazosin Hydrochloride is a synthetic piperazine derivative with hypotensive antiadrenergic properties, It is used in the treatment of heart failure, hypertension, pheochromocytoma, Raynaud's syndrome, prostatic hypertrophy, and urinary retention.
CAS:
19237-84-4
Formula:
C19H22ClN5O4
Molecular Weight:
419.87
Pathway:
Neuroscience; Autophagy; Membrane transporter/Ion channel; Immunology/Inflammation; GPCR/G Protein
Purity:
0.9987
SMILES:
Cl.COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1
Target:
Potassium Channel; MRP; Adrenergic Receptor; ABC; Autophagy
References
1. Baum O, et al. Am J Physiol Heart Circ Physiol,2004, 287(5), H2300-H2308.
2. Donoso MV, et al. J Pharmacol Exp Ther,1997, 282(2), 691-698.
3. L? AD, et al. Psychopharmacology (Berl),2011, 218(1), 89-99.
4. Wadenberg ML, et al. J Neural Transm, 2000, 107(10), 1229-1238.
5. Math? JM, et al. Eur J Pharmacol,1996, 309(1), 1-11.
6. Bowden G D, Land K M, O'Connor R M, et al. High-throughput screen of drug repurposing library identifies inhibitors of Sarcocystis neurona growth[J]. International Journal for Parasitology: Drugs and Drug Resistance. 2018 Apr?8(1): 137-144.