TargetMol

Pamufetinib

Product Code:
 
TAR-T13108
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T13108-1mg1mg£132.00
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TAR-T13108-5mg5mg£215.00
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TAR-T13108-1mL1 mL * 10 mM (in DMSO)£252.00
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TAR-T13108-10mg10mg£284.00
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TAR-T13108-25mg25mg£433.00
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TAR-T13108-50mg50mg£603.00
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TAR-T13108-100mg100mg£830.00
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Further Information

Bioactivity:
TAS-115 is a potent inhibitor of VEGFR and hepatocyte growth factor receptor (c-Met/HGFR)-targeted kinase(IC50s of 30 and 32 nM for rVEGFR2 and rMET, respectively).
CAS:
1190836-34-0
Formula:
C27H23FN4O4S
Molecular Weight:
518.56
Pathway:
Angiogenesis; Tyrosine Kinase/Adaptors
Purity:
0.9915
SMILES:
CNC(=O)c1cc2c(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)ccnc2cc1OC
Target:
VEGFR; c-Met/HGFR

References

1. Fujita H, et al. The novel VEGF receptor/MET-targeted kinase inhibitor TAS-115 has marked in vivo antitumor properties and a favorable tolerability profile. Mol Cancer Ther. 2013 Dec;12(12):2685-96. 2. Nakade J, et al. Triple inhibition of EGFR, Met, and VEGF suppresses regrowth of HGF-triggered, erlotinib-resistant lung cancer harboring an EGFR mutation. J Thorac Oncol. 2014 Jun;9(6):775-83.