Perindopril erbumine
| Code | Size | Price |
|---|
| TAR-T1484L-100mg | 100mg | £112.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T1484L-200mg | 200mg | £133.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Perindopril Erbumine is the tert-butylamine salt of perindopril, the ethyl ester of a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Upon hydrolysis, perindopril erbumine is converted to its active form perindoprilat, inhibiting ACE and the conversion of angiotensin I to angiotensin II; consequently, angiotensin II-mediated vasoconstriction and angiotensin II-stimulated aldosterone secretion from the adrenal cortex are inhibited and diuresis and natriuresis ensue.
CAS:
107133-36-8
Formula:
C23H43N3O5
Molecular Weight:
441.613
Pathway:
Apoptosis; Immunology/Inflammation; Endocrinology/Hormones
Purity:
0.998
SMILES:
CC(C)(C)N.[H][C@]12C[C@H](N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@@]1([H])CCCC2)C(O)=O
Target:
Apoptosis; RAAS; MRP
References
1. Ceconi C, et al. Eur J Pharmacol, 2007, 577(1-3), 1-6.
2. Zou K, et al. J Biol Chem, 2009, 284(46), 31914-31920.
3. Yasumatsu R, et al. J Cancer Res Clin Oncol, 2004, 130(10), 567-573.
4. Yoshiji H, et al. Clin Cancer Res, 2001, 7(4), 1073-1078.
5. Ceconi C, et al. Cardiovasc Drugs Ther, 2007, 21(6), 423-429.