LP-922761
| Code | Size | Price |
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| TAR-T15780-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T15780-50mg | 50mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
LP-922761 is an effective, selective, and orally active adapter protein-2 associated kinase 1 (AAK1) inhibitor (IC50: 4.8 nM and a cellular IC50: 7.6 nM). LP-922761 also inhibits BMP-2-inducible protein kinase (BIKE) (IC50: 24 nM). LP-922761 shows no significant activity at cyclin G-associated kinase (GAK), opioid, adrenergic α2, or GABAa receptors.
CAS:
1454808-95-7
Formula:
C21H26N6O3
Molecular Weight:
410.478
Purity:
0.98
SMILES:
CN(CCNc1ccc2ncc(-c3ccc(cc3)C(N)=O)n2n1)C(=O)OC(C)(C)C
References
1. Kostich W, et al. Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain. J Pharmacol Exp Ther. 2016 Sep;358(3):371-86.