Lomustine
| Code | Size | Price |
|---|
| TAR-T1601-1mL | 1 mL * 10 mM (in DMSO) | £111.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T1601-100mg | 100mg | £111.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T1601-200mg | 200mg | £139.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Lomustine is an alkylating agent of value against both hematologic malignancies and solid tumors.
CAS:
13010-47-4
Formula:
C9H16ClN3O2
Molecular Weight:
233.7
Pathway:
; DNA Damage/DNA Repair; Apoptosis; Autophagy
Purity:
0.9986
SMILES:
ClCCN(N=O)C(=O)NC1CCCCC1
Target:
Apoptosis; DNA Alkylator/Crosslinker; DNA Alkylation; Autophagy
References
1. Baer JC, et al. Br J Cancer, 1993, 67(6), 1299-12302.
2. Shinwari Z, et al. J Neurooncol, 2008, 87(2), 123-132.
3. Rassnick KM, et al. J Vet Intern Med, 1999, 13(6), 601-605.
4. Kristal O, et al. J Vet Intern Med, 2004, 18(1), 75-80.
5. Fan TM, et al. J Am Anim Hosp Assoc, 2002, 38(4), 357-363.
6. Wang P, et al. Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents. Cell Rep. 2015 Dec 22;13(11):2353-2361.
7. Harvey KA, et al. Enhanced anticancer properties of lomustine in conjunction with docosahexaenoic acid in glioblastoma cell lines. J Neurosurg. 2015 Mar;122(3):547-56.
8. Yagiz K, et al. Toca 511 plus 5-fluorocytosine in combination with lomustine shows chemotoxic and immunotherapeutic activity with no additive toxicity in rodent glioblastoma models. Neuro Oncol. 2016 Oct;18(10):1390-401.