NKH477

TargetMol
Product Code: TAR-T16332
Supplier: TargetMol
CodeSizePrice
TAR-T16332-100mg100mgEnquire
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TAR-T16332-50mg50mgEnquire
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Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Further Information

Bioactivity:
NKH477 is a novel water-soluble forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 shows an antiproliferative effect in vivo with an altered cytokine profile to inhibit the acute rejection of rat orthotopic lung allografts. NKH477 directly activates the catalytic unit of adenylate cyclase and enhances intracellular cAMP .
CAS:
138605-00-2
Formula:
C27H44ClNO8
Molecular Weight:
546.1
Pathway:
Neuroscience
Purity:
0.98
SMILES:
Cl.[H][C@@]12[C@H](OC(=O)CCN(C)C)[C@H](OC(C)=O)[C@@]3(C)O[C@](C)(CC(=O)[C@]3(O)[C@@]1(C)[C@@H](O)CCC2(C)C)C=C
Target:
NMDAR

References

1. Nakashima S, et al. Antiproliferative effects of NKH477, a forskolin derivative, on cytokine profile in rat lung allografts. J Heart Lung Transplant. 2005 Apr;24(4):462-9.