2-Fluoroadenine
| Code | Size | Price |
|---|
| TAR-T20038-100mg | 100mg | £103.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T20038-1mL | 1 mL * 10 mM (in DMSO) | £107.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T20038-200mg | 200mg | £114.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
2-Fluoroadenine has toxicity in nonproliferating and proliferating tumor cells. 2-Fluoroadenine can be used for anticancer studies.
CAS:
700-49-2
Formula:
C5H4FN5
Molecular Weight:
153.12
Pathway:
Cell Cycle/Checkpoint; DNA Damage/DNA Repair
Purity:
0.98
SMILES:
Nc1[nH]c(F)nc2ncnc12
Target:
DNA/RNA Synthesis
References
1. Rackwitz J, Kopyra J, D?bkowska I, Ebel K, Rankovi? MLj, Milosavljevi? AR, Bald I. Sensitizing DNA Towards Low-Energy Electrons with 2-Fluoroadenine. Angew Chem Int Ed Engl. 2016 Aug 22;55(35):10248-52. doi: 10.1002/anie.201603464. Epub 2016 Aug 2. PubMed PMID: 27481662.
2. Collonnier C, Epert A, Mara K, Maclot F, Guyon-Debast A, Charlot F, White C, Schaefer DG, Nogu? F. CRISPR-Cas9-mediated efficient directed mutagenesis and RAD51-dependent and RAD51-independent gene targeting in the moss Physcomitrella patens. Plant Biotechnol J. 2017 Jan;15(1):122-131. doi: 10.1111/pbi.12596. Epub 2016 Jul 22. PubMed PMID: 27368642; PubMed Central PMCID: PMC5253467.
3. Hassan AE, Abou-Elkhair RA, Parker WB, Allan PW, Secrist JA 3rd. 6-Methylpurine derived sugar modified nucleosides: Synthesis and evaluation of their substrate activity with purine nucleoside phosphorylases. Bioorg Chem. 2016 Apr;65:9-16. doi: 10.1016/j.bioorg.2015.12.006. Epub 2015 Dec 24. PubMed PMID: 26745284.
4. Hassan AEA, Abou-Elkhair RAI, Parker WB, Allan PW, Secrist JA 3rd. 6-Methylpurine derived sugar modified nucleosides: Synthesis and in vivo antitumor activity in D54 tumor expressing M64V-Escherichia coli purine nucleoside phosphorylase. Eur J Med Chem. 2016 Jan 27;108:616-622. doi: 10.1016/j.ejmech.2015.12.029. Epub 2015 Dec 17. PubMed PMID: 26724729.