PD-166793
| Code | Size | Price |
|---|
| TAR-T20563-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T20563-50mg | 50mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
PD-166793 is a cell-permeable biphenylsulfonylvaline compound. It is an inhibitor against MMP-2, MMP-3, and MMP-13 (IC50s: 47, 12, and 8 nM). PD-166793 is also a weaker inhibitor against AMP deaminase (20% inhibition at 0.1 μM), MMP-1, MMP-7, MMP-9, and MMP-14 (IC50s: 6.1, 7.2, 7.9, and 0.24 μM).
CAS:
199850-67-4
Formula:
C17H18BrNO4S
Molecular Weight:
412.3
Purity:
0.98
SMILES:
CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(Br)cc1)C(O)=O
References
1. Kaludercic N, Lindsey ML, Tavazzi B, Lazzarino G, Paolocci N. Inhibiting metalloproteases with PD 166793 in heart failure: impact on cardiac remodeling and beyond. Cardiovasc Ther. 2008 Spring;26(1):24-37. doi: 10.1111/j.1527-3466.2007.00034.x. Review. PubMed PMID: 18466418.
2. Mendes O, Kim HT, Stoica G. Expression of MMP2, MMP9 and MMP3 in breast cancer brain metastasis in a rat model. Clin Exp Metastasis. 2005;22(3):237-46. PubMed PMID: 16158251.
3. Wang W, Sawicki G, Schulz R. Peroxynitrite-induced myocardial injury is mediated through matrix metalloproteinase-2. Cardiovasc Res. 2002 Jan;53(1):165-74. PubMed PMID: 11744025.
4. Chancey AL, Brower GL, Peterson JT, Janicki JS. Effects of matrix metalloproteinase inhibition on ventricular remodeling due to volume overload. Circulation. 2002 Apr 23;105(16):1983-8. PubMed PMID: 11997287.