Cromakalim
| Code | Size | Price |
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| TAR-T21478-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T21478-50mg | 50mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Cromakalim, a potassium channel-opening vasodilator, acts on ATP-sensitive potassium channels and so causes membrane hyperpolarization, it can be used to treat hypertension as it will relax vascular smooth muscle to lower blood pressure. The active isomer is levcromakalim.
CAS:
94470-67-4
Formula:
C16H18N2O3
Molecular Weight:
286.33
Purity:
0.98
SMILES:
N#CC1=CC([C@@H](N2C(CCC2)=O)[C@H](O)C(C)(C)O3)=C3C=C1
References
1. Cecchetti V, Tabarrini O, Sabatini S. From cromakalim to different structural classes of K(ATP) channel openers. Curr Top Med Chem. 2006;6(10):1049-68. Review. PubMed PMID: 16787279.
2. Moreau C, Prost AL, D?rand R, Vivaudou M. SUR, ABC proteins targeted by KATP channel openers. J Mol Cell Cardiol. 2005 Jun;38(6):951-63. Epub 2005 Feb 19. Review. PubMed PMID: 15910880.
3. Khan IA, Gowda RM. Novel therapeutics for treatment of long-QT syndrome and torsade de pointes. Int J Cardiol. 2004 May;95(1):1-6. Review. PubMed PMID: 15159030.
4. Sebille S, De Tullio P, Boverie S, Antoine MH, Lebrun P, Pirotte B. Recent developments in the chemistry of potassium channel activators: the cromakalim analogs. Curr Med Chem. 2004 May;11(9):1213-22. Review. PubMed PMID: 15134515.