A1899
| Code | Size | Price |
|---|
| TAR-T24993-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24993-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24993-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
A1899 is a effective and selective TASK-1 and TASK-3 antagonist.
CAS:
498577-46-1
Formula:
C30H26F2N2O3
Molecular Weight:
500.546
Purity:
0.98
SMILES:
COc1ccc(CC(=O)NCc2ccccc2-c2ccccc2C(=O)NCc2ccc(F)cc2F)cc1
References
1. Ram?rez D, Ar?valo B, Mart?nez G, Rinn? S, Sep?lveda FV, Decher N, Gonz?lez W. Side Fenestrations Provide an "Anchor" for a Stable Binding of A1899 to the Pore of TASK-1 Potassium Channels. Mol Pharm. 2017 Jul 3;14(7):2197-2208. doi: 10.1021/acs.molpharmaceut.7b00005. Epub 2017 May 30. PubMed PMID: 28494157.
2. Guarina L, Vandael DH, Carabelli V, Carbone E. Low pH(o) boosts burst firing and catecholamine release by blocking TASK-1 and BK channels while preserving Cav1 channels in mouse chromaffin cells. J Physiol. 2017 Apr 15;595(8):2587-2609. doi: 10.1113/JP273735. Epub 2017 Mar 2. PubMed PMID: 28026020; PubMed Central PMCID: PMC5390891.
3. Chokshi RH, Larsen AT, Bhayana B, Cotten JF. Breathing Stimulant Compounds Inhibit TASK-3 Potassium Channel Function Likely by Binding at a Common Site in the Channel Pore. Mol Pharmacol. 2015 Nov;88(5):926-34. doi: 10.1124/mol.115.100107. Epub 2015 Aug 12. PubMed PMID: 26268529; PubMed Central PMCID: PMC4613942.
4. Dadi PK, Luo B, Vierra NC, Jacobson DA. TASK-1 Potassium Channels Limit Pancreatic ?-Cell Calcium Influx and Glucagon Secretion. Mol Endocrinol. 2015 May;29(5):777-87. doi: 10.1210/me.2014-1321. Epub 2015 Apr 7. PubMed PMID: 25849724; PubMed Central PMCID: PMC4415209.