TargetMol

4-POBN

Product Code:
 
TAR-T26389
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T26389-100mg100mg£103.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T26389-1mL1 mL * 10 mM (in DMSO)£107.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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Further Information

Bioactivity:
4-POBN is a potent and irreversible inhibitor of myeloperoxidase (IC50 = 0.3 ?M). 4-POBN can be used in studies about subacute stroke.
CAS:
5351-17-7
Formula:
C7H9N3O
Molecular Weight:
151.169
Pathway:
Metabolism
Purity:
0.98
SMILES:
NNC(=O)c1ccc(N)cc1
Target:
Glutathione Peroxidase

References

1. Arvadia P, et al. 4-Aminobenzoic acid hydrazide inhibition of microperoxidase-11: catalytic inhibition by reactive metabolites. Arch Biochem Biophys. 2011 Nov;515(1-2):120-6. 2. Smith G, Lynch DE. Crystal structures of two erbium(III) complexes with 4-amino-benzoic acid and 4-chloro-3-nitro-benzoic acid. Acta Crystallogr E Crystallogr Commun. 2015 Nov 7;71(Pt 12):1457-61. 3. Kettle AJ, et al. Inhibition of myeloperoxidase by benzoic acid hydrazides. Biochem J. 1995 Jun 1;308 ( Pt 2)(Pt 2):559-63. 4. Forghani R, et al. Myeloperoxidase propagates damage and is a potential therapeutic target for subacute stroke. J Cereb Blood Flow Metab. 2015 Mar;35(3):485-93.