NSC668394
| Code | Size | Price |
|---|
| TAR-T28212-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T28212-50mg | 50mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
NSC-668394 is an ezrin inhibitor. NSC-668394 inhibits ezrin phosphorylation, ezrin-actin interaction and ezrin-mediated motility of osteosarcoma (OS) cells in culture.
CAS:
382605-72-3
Formula:
C17H12Br2N2O3
Molecular Weight:
452.102
Purity:
0.98
SMILES:
Oc1c(Br)cc(CCNC2=CC(=O)c3cccnc3C2=O)cc1Br
References
1. Andharia N, Joseph A, Hayashi M, Okada M, Matsuda H. Involvement of intracellular transport in TREK-1c current run-up in 293T cells. Channels (Austin). 2017 May 4;11(3):224-235. doi: 10.1080/19336950.2017.1279368. Epub 2017 Jan 13. PubMed PMID: 28085542; PubMed Central PMCID: PMC5463894.
2. ?elik H, Bulut G, Han J, Graham GT, Minas TZ, Conn EJ, Hong SH, Pauly GT, Hayran M, Li X, ?zdemirli M, Ayhan A, Rudek MA, Toretsky JA, ?ren A. Ezrin Inhibition Up-regulates Stress Response Gene Expression. J Biol Chem. 2016 Jun 17;291(25):13257-70. doi: 10.1074/jbc.M116.718189. Epub 2016 May 2. PubMed PMID: 27137931; PubMed Central PMCID: PMC4933238.
3. Pore D, Bodo J, Danda A, Yan D, Phillips JG, Lindner D, Hill BT, Smith MR, Hsi ED, Gupta N. Identification of Ezrin-Radixin-Moesin proteins as novel regulators of pathogenic B-cell receptor signaling and tumor growth in diffuse large B-cell lymphoma. Leukemia. 2015 Sep;29(9):1857-67. doi: 10.1038/leu.2015.86. Epub 2015 Mar 24. PubMed PMID: 25801911; PubMed Central PMCID: PMC4558318.
4. Ren L, Khanna C. Role of ezrin in osteosarcoma metastasis. Adv Exp Med Biol. 2014;804:181-201. doi: 10.1007/978-3-319-04843-7_10. Review. PubMed PMID: 24924175.