Fluorizoline
| Code | Size | Price |
|---|
| TAR-T31821-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T31821-50mg | 50mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Fluorizoline is an inducer of p53 independent apoptosis in a variety of tumor cell lines.
CAS:
1362243-70-6
Formula:
C15H8Cl2F3NS
Molecular Weight:
362.19
Purity:
0.98
SMILES:
FC1(F)N=C(SC1(F)c1ccc(Cl)cc1)c1ccc(Cl)cc1
References
1. Wierz M, Pierson S, Chouha N, D?saubry L, Fran?ois JH, Berchem G, Paggetti J, Moussay E. The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells ex vivo but fails to prevent leukemia development in a murine model. Haematologica. 2018 Jan 5. pii: haematol.2017.175349. doi: 10.3324/haematol.2017.175349. [Epub ahead of print] PubMed PMID: 29305413.
2. Cosialls AM, Pomares H, Iglesias-Serret D, Saura-Esteller J, N??ez-V?zquez S, Gonz?lez-Giron?s DM, de la Banda E, Preciado S, Albericio F, Lavilla R, Pons G, Gonz?lez-Barca EM, Gil J. The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells through the upregulation of NOXA and synergizes with ibrutinib, 5-aminoimidazole-4-carboxamide riboside or venetoclax. Haematologica. 2017 Sep;102(9):1587-1593. doi: 10.3324/haematol.2016.162958. Epub 2017 Jun 15. PubMed PMID: 28619845; PubMed Central PMCID: PMC5685241.
3. Yurugi H, Marini F, Weber C, David K, Zhao Q, Binder H, D?saubry L, Rajalingam K. Targeting prohibitins with chemical ligands inhibits KRAS-mediated lung tumours. Oncogene. 2017 Aug 17;36(33):4778-4789. doi: 10.1038/onc.2017.93. Epub 2017 Apr 17. Erratum in: Oncogene. 2017 Aug 28;:. PubMed PMID: 28414306.
4. Pomares H, Palmeri CM, Iglesias-Serret D, Moncunill-Massaguer C, Saura-Esteller J, N??ez-V?zquez S, Gamundi E, Arnan M, Preciado S, Albericio F, Lavilla R, Pons G, Gonz?lez-Barca EM, Cosialls AM, Gil J. Targeting prohibitins induces apoptosis in acute myeloid leukemia cells. Oncotarget. 2016 Oct 4;7(40):64987-65000. doi: 10.18632/oncotarget.11333. PubMed PMID: 27542247; PubMed Central PMCID: PMC5323132.