TargetMol

CX08005

Product Code:
 
TAR-T37184
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T37184-5mg5mg£850.00
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Quantity:
TAR-T37184-50mg50mg£1,661.00
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Quantity:
TAR-T37184-100mg100mg£2,079.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
Competitive PTP1B inhibitor (IC50 = 0.781 μM). Binds catalytic P-loop of enzyme. Improves insulin sensitivity in obese mice in the glucose tolerance test and the homeostasis model assessment of insulin resistance index (HOMA-IR). Enhances insulin-induced glucose uptake in adipocytes and myotubes in vitro. Exhibits some selectivity for PTP1B over other protein tyrosine phosphatases, except TCPTP.
CAS:
1256341-22-6
Formula:
C28H39N04
Molecular Weight:
453.61
Purity:
0.98
SMILES:
CCCCCCCCCCCCCCOC1=C(C=CC=C1)NC(C2=C(C(O)=O)C=CC=C2)=O

References

Zhang et al (2016) A novel protein tyrosine phosphatase 1B inhibitor with therapeutic potential for Ins resistance. Br.J.Pharmacol. 173 1939 PMID:26990621