5β-Dihydroprogesterone
| Code | Size | Price |
|---|
| TAR-T37319-100mg | 100mg | £310.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T37319-500mg | 500mg | £711.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
5β-Dihydroprogesterone (5β-DHP) is a progesterone receptor agonist and metabolite of progesterone .1,2It is formed from progesterone by 5β-reductase.25β-DHP inhibits spontaneous contractions in isolated rat uterus when used at a concentration of 10 μg/ml, an effect that can be blocked by the progesterone receptor antagonist RU486 but not the GABAAreceptor antagonist picrotoxin .1It is a negative modulator of homooligomeric ?1 subunit-containing GABAAreceptors, inhibiting GABA-induced currents inX. laevisoocytes expressing these receptors (IC50= 5.02 μM).3Plasma levels of 5β-DHP decrease at the onset of spontaneous human labor.4
CAS:
128-23-4
Formula:
C21H32O2
Molecular Weight:
316.5
Purity:
0.98
SMILES:
C[C@@]12[C@]3([H])[C@](CC[C@]1([H])CC(CC2)=O)([H])[C@@]4([H])[C@](CC3)([C@H](CC4)C(C)=O)C
References
Bumke-Vogt, C., B?hr, V., Diederich, S., et al.Expression of the progesterone receptor and progesterone- metabolising enzymes in the female and male human kidneyJ. Endocrinol.175(2)349-364(2002)
Sheehan, P.M., Rice, G.E., Moses, E.K., et al.5?-dihydroprogesterone and steroid 5?-reductase decrease in association with human parturition at termMol. Hum. Reprod.11(7)495-501(2005)
Putnam, C.D., Brann, D.W., Kolbeck, R.C., et al.Inhibition of uterine contractility by progesterone and progesterone metabolites: Mediation by progesterone and gamma amino butyric acidA receptor systemsBiol. Reprod.45(2)266-272(1991)
Morris, K.D., Moorefield, C.N., and Amin, J.Differential modulation of the ?-aminobutyric acid type C receptor by neuroactive steroidsMol. Pharmacol.56(4)752-759(1999)