GW 1929 hydrochloride
| Code | Size | Price |
|---|
| TAR-T37579-100mg | 100mg | £915.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Highly selective orally active peroxisome proliferator-activated receptor (PPAR)γ agonist (pEC50 values are 8.05, < 4 and < 4 for human PPARγ, PPARα and PPARδ receptors respectively). Decreases glucose, fatty acid and triglyceride levels following oral administration in vivo.
CAS:
1217466-21-1
Formula:
C30H29N3O4.HCl
Molecular Weight:
532.03
Purity:
0.98
SMILES:
Cl.CN(CCOC1=CC=C(C[C@H](NC2=CC=CC=C2C(=O)C2=CC=CC=C2)C(O)=O)C=C1)C1=NC=CC=C1
References
Brown et al (1999) A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-? reverses the diabetic phenotype of the Zucker diabetic fatty rat. Diabetes 48 1415 PMID:10389847
Way et al (2001) Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor ? agonists. J.Biol.Chem. 276 25651 PMID:11373275
Nugent et al (2001) Potentiation of glucose uptake in 3T3-L1 adipocytes by PPAR? agonists is maintained in cells expressing a PPAR? dominant-negative mutant: evidence for selectivity in the downstream responses to PPAR? activation. Mol.Endocrinol. 15 1729 PMID:11579205