Fumaric acid
| Code | Size | Price |
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| TAR-T3763-1mL | 1 mL * 10 mM (in DMSO) | £99.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Fumaric acid attenuates the eotaxin-1 expression in TNF-α-stimulated fibroblasts by suppressing p38 MAPK-dependent NF-κB signaling. Fumaric acid has recently been identified as an oncometabolite or an endogenous, cancer-causing metabolite. High levels of this organic acid can be found in tumors or biofluids surrounding tumors. Its oncogenic action appears due to its ability to inhibit prolyl hydroxylase-containing enzymes.
CAS:
110-17-8
Formula:
C4H4O4
Molecular Weight:
116.072
Pathway:
Metabolism
Purity:
0.98
SMILES:
OC(=O)C=CC(O)=O
Target:
Endogenous Metabolite
References
Roh KB, et al. Fumaric acid attenuates the eotaxin-1 expression in TNF-?-stimulated fibroblasts by suppressing p38 MAPK-dependent NF-?B signaling. Food Chem Toxicol. 2013 Aug;58:423-31.
Chen X, et al. Fumaric acid production by Torulopsis glabrata: engineering the urea cycle and the purine nucleotide cycle. Biotechnol Bioeng. 2015 Jan;112(1):156-67.