AM404
| Code | Size | Price |
|---|
| TAR-T39281-100mg | 100mg | £1,595.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
AM404, an inhibitor of endocannabinoid reuptake , blocks anandamide transport with IC 50 values in the low micromolar range. AM404 is able to relax rat isolated hepatic arteries contracted with Phenylephrine, with a pEC 50 value of 7.4 (corresponding to an EC 50 of 0.04 μM). Neuroprotective Effect.
CAS:
183718-77-6
Formula:
C26H37NO2
Molecular Weight:
395.587
Purity:
0.98
SMILES:
CCCCCC=C/CC=C/CC=C/CC=C/CCCC(=O)Nc1ccc(O)cc1
References
Marco Bortolato, et al. Anxiolytic-like properties of the anandamide transport inhibitor AM404. Neuropsychopharmacology. 2006 Dec;31(12):2652-9.
Kent-Olov Jonsson, et al. AM404 and VDM 11 non-specifically inhibit C6 glioma cell proliferation at concentrations used to block the cellular accumulation of the endocannabinoid anandamide. Arch Toxicol. 2003 Apr;77(4):201-7.
A Giuffrida, et al. Mechanisms of endocannabinoid inactivation: biochemistry and pharmacology. J Pharmacol Exp Ther. 2001 Jul;298(1):7-14.