TH5427 hydrochloride
Code | Size | Price |
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TAR-T39785-100mg | 100mg | £1,254.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
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Further Information
Bioactivity:
TH5427 hydrochloride is a potent, selective NUDT5 inhibitor ( IC 50 =29 nM). TH5427 hydrochloride shows an apparent 690-fold selectivity for NUDT5 over MTH1. TH5427 hydrochloride blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells.
CAS:
2253744-57-7
Formula:
0
Molecular Weight:
0
Purity:
0.98
SMILES:
0
References
Page BDG, et al. Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells [published correction appears in Nat Commun. 2019 Nov 1;10(1):5050]. Nat Commun. 2018;9(1):250. Published 2018 Jan 17.