TargetMol

3-Hydroxyanthranilic acid

Product Code:
 
TAR-T4707
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T4707-1mL1 mL * 10 mM (in DMSO)£107.00
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TAR-T4707-100mg100mg£124.00
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Further Information

Bioactivity:
3-Hydroxyanthranilic acid, also known as 2-amino-3-hydroxy-benzoate or 3-ohaa, belongs to the class of organic compounds known as hydroxybenzoic acid derivatives. 3-Hydroxyanthranilic acid has been found in human epidermis and bladder tissues, and has also been detected in multiple biofluids, such as urine and blood. Within the cell, 3-hydroxyanthranilic acid is primarily located in the cytoplasm. 3-Hydroxyanthranilic acid exists in all eukaryotes, ranging from yeast to humans. 3-Hydroxyanthranilic acid participates in a number of enzymatic reactions. In particular, 3-Hydroxyanthranilic acid and L-alanine can be biosynthesized from L-3-hydroxykynurenine; which is catalyzed by the enzyme kynureninase. Furthermore, 3-Hydroxyanthranilic acid can be converted into cinnavalininate through its interaction with the enzyme catalase. Furthermore, L-Alanine and 3-hydroxyanthranilic acid can be biosynthesized from 3-hydroxy-L-kynurenine through its interaction with the enzyme kynureninase. Furthermore, 3-Hydroxyanthranilic acid can be converted into 2-amino-3-carboxymuconic acid semialdehyde; which is catalyzed by the enzyme 3-hydroxyanthranilate 3,4-dioxygenase. Furthermore, 3-Hydroxyanthranilic acid can be converted into 2-amino-3-carboxymuconic acid semialdehyde through the action of the enzyme 3-hydroxyanthranilate 3,4-dioxygenase. Finally, L-Alanine and 3-hydroxyanthranilic acid can be biosynthesized from 3-hydroxy-L-kynurenine; which is mediated by the enzyme kynureninase. In humans, 3-hydroxyanthranilic acid is involved in the tryptophan metabolism pathway.
CAS:
548-93-6
Formula:
C7H7NO3
Molecular Weight:
153.137
Pathway:
; Metabolism
Purity:
0.9998
SMILES:
Nc1c(O)cccc1C(O)=O
Target:
Endogenous Metabolite

References

Hegedus Z L , Frank H A , Altschule M D , et al. Human plasma lipofuscin melanins formed from tryptophan metabolites[J]. Archives Internationales de Physiologie, 1986, 94(5):10. Teulings F A , Mulderkooy G E , Peters H A , et al. The excretion of 3-hydroxyanthranilic acid in patients with bladder and kidney carcinoma.[J]. Acta Vitaminol Enzymol, 1975, 29(1-6):108-112. Calandra P . Research on tryptophan metabolites "via kynurenine" in epidermis of man and mouse.[J]. Acta Vitaminol Enzymol, 1975, 29(1-6):158-160. Antoni A D , Rubaltelli F F , Costa C , et al. Effect of phototherapy on the urinary excretion of tryptophan metabolites in neonatal hyperbilirubinemia.[J]. Acta Vitaminologica Et Enzymologica, 1975, 29(1-6):145. Werner E R , Lutz H , Fuchs D , et al. Identification of 3-Hydroxyanthranilic Acid in Mixed Lymphocyte Cultures[J]. Biological Chemistry, 1985, 366(1):99-102.