Erucic acid
| Code | Size | Price |
|---|
| TAR-T4867-100mg | 100mg | £107.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T4867-1mL | 1 mL * 10 mM (in DMSO) | £109.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Increased levels of erucic acid (22:1n9) have been found in the red blood cell membranes of autistic subjects with developmental regression (PMID: 16581239 ). Erucic acid is broken down long-chain acyl-coenzyme A (CoA) dehydrogenase, which is produced in the liver. This enzyme breaks this long chain fatty acid into shorter-chain fatty acids. human infants have relatively low amounts of this enzyme and because of this, babies should not be given foods high in erucic acid. Erucic acid is found to be associated with isovaleric acidemia, which is an inborn error of metabolism.
CAS:
112-86-7
Formula:
C22H42O2
Molecular Weight:
338.576
Pathway:
Metabolism; PI3K/Akt/mTOR signaling
Purity:
0.98
SMILES:
CCCCCCCCC=C/CCCCCCCCCCCC(O)=O
Target:
PI3K; Endogenous Metabolite
References
Dercksen M , Kulik W , Mienie L J , et al. Polyunsaturated fatty acid status in treated isovaleric acidemia patients[J]. European Journal of Clinical Nutrition, 2016, 70(10).
Rizzo W B , Leshner R T , Odone A , et al. Dietary erucic acid therapy for X?linked adrenoleukodystrophy[J]. Neurology, 1989, 39(11):1415-1422.
Kim E, et al. The memory-enhancing effect of erucic acid on scopolamine-induced cognitive impairment in mice. Pharmacol Biochem Behav. 2016 Mar;142:85-90.
Bu B , Ashwood P , Harvey D , et al. Fatty acid compositions of red blood cell phospholipids in children with autism[J]. Prostagrandins Leukot Essent Fatty Acids, 2006, 74(4):215-221.
Aubourg P , Adamsbaum C , Lavallardrousseau M C , et al. A two-year trial of oleic and erucic acids ("Lorenzo's oil") as treatment for adrenomyeloneuropathy.[J]. New England Journal of Medicine, 1993, 329(11):745.
Brown D G , Rao S , Weir T L , et al. Metabolomics and metabolic pathway networks from human colorectal cancers, adjacent mucosa, and stool[J]. Cancer & Metabolism, 2016, 4(1):11.