TargetMol

Erucic acid

Product Code:
 
TAR-T4867
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4867-100mg100mg£107.00
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Quantity:
TAR-T4867-1mL1 mL * 10 mM (in DMSO)£109.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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Further Information

Bioactivity:
Increased levels of erucic acid (22:1n9) have been found in the red blood cell membranes of autistic subjects with developmental regression (PMID: 16581239 ). Erucic acid is broken down long-chain acyl-coenzyme A (CoA) dehydrogenase, which is produced in the liver. This enzyme breaks this long chain fatty acid into shorter-chain fatty acids. human infants have relatively low amounts of this enzyme and because of this, babies should not be given foods high in erucic acid. Erucic acid is found to be associated with isovaleric acidemia, which is an inborn error of metabolism.
CAS:
112-86-7
Formula:
C22H42O2
Molecular Weight:
338.576
Pathway:
Metabolism; PI3K/Akt/mTOR signaling
Purity:
0.98
SMILES:
CCCCCCCCC=C/CCCCCCCCCCCC(O)=O
Target:
PI3K; Endogenous Metabolite

References

Dercksen M , Kulik W , Mienie L J , et al. Polyunsaturated fatty acid status in treated isovaleric acidemia patients[J]. European Journal of Clinical Nutrition, 2016, 70(10). Rizzo W B , Leshner R T , Odone A , et al. Dietary erucic acid therapy for X?linked adrenoleukodystrophy[J]. Neurology, 1989, 39(11):1415-1422. Kim E, et al. The memory-enhancing effect of erucic acid on scopolamine-induced cognitive impairment in mice. Pharmacol Biochem Behav. 2016 Mar;142:85-90. Bu B , Ashwood P , Harvey D , et al. Fatty acid compositions of red blood cell phospholipids in children with autism[J]. Prostagrandins Leukot Essent Fatty Acids, 2006, 74(4):215-221. Aubourg P , Adamsbaum C , Lavallardrousseau M C , et al. A two-year trial of oleic and erucic acids ("Lorenzo's oil") as treatment for adrenomyeloneuropathy.[J]. New England Journal of Medicine, 1993, 329(11):745. Brown D G , Rao S , Weir T L , et al. Metabolomics and metabolic pathway networks from human colorectal cancers, adjacent mucosa, and stool[J]. Cancer & Metabolism, 2016, 4(1):11.