TargetMol

Nordihydroguaiaretic acid

Product Code:
 
TAR-TJS2190
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TJS2190-100mg100mg£111.00
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TAR-TJS2190-1mL1 mL * 10 mM (in DMSO)£115.00
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TAR-TJS2190-250mg250mg£148.00
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TAR-TJS2190-500mg500mg£186.00
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Further Information

Bioactivity:
Nordihydroguaiaretic acid (NDGA) is a phenolic antioxidant found in the leaves and twigs of the evergreen desert shrub, Larrea tridentata (Sesse and Moc. ex DC) Coville (creosote bush). It is a recognized inhibitor of lipoxygenase (LOX) and has antioxidant and free radical scavenging properties.
CAS:
500-38-9
Formula:
C18H22O4
Molecular Weight:
302.37
Pathway:
Autophagy; Apoptosis; oxidation-reduction; Cell Cycle/Checkpoint; Metabolism
Purity:
0.9991
SMILES:
CC(CC1=CC(=C(C=C1)O)O)C(C)CC2=CC(=C(C=C2)O)O
Target:
Antioxidant; Ferroptosis; Lipoxygenase; Autophagy

References

West M, et al. The arachidonic acid 5-lipoxygenase inhibitor Nordihydroguaiaretic acid inhibits tumor necrosis factor alpha activation of microglia and extends survival of G93A-SOD1 transgenic mice. J Neurochem. 2004 Oct;91(1):133-43. Zhang H, et al. Nordihydroguaiaretic acid improves metabolic dysregulation and aberrant hepatic lipid metabolism in mice by both PPAR?-dependent and -independent pathways. Am J Physiol Gastrointest Liver Physiol. 2013 Jan 1;304(1):G72-86. Lu F, et al. Virtual Screening for Potential Allosteric Inhibitors of Cyclin-Dependent Kinase 2 from Traditional Chinese Medicine. Molecules. 2016 Sep 21;21(9). pii: E1259.