Prochloraz
Code | Size | Price |
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TAR-T20625-200mg | 200mg | £98.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T20625-1mL | 1 mL * 10 mM (in DMSO) | £107.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
Prochloraz is a broad-spectrum contact imidazole fungicide. Prochloraz inhibits human placental microsomal aromatase in vitro (IC50 = 40 nM). Prochloraz also acts as an estrogen receptor (IC50s = 25 μM) and androgen receptor (IC50 = 4 μM) antagonist, and activates aryl hydrocarbon receptors (EC50 = 1 μM).
CAS:
67747-09-5
Formula:
C15H16Cl3N3O2
Molecular Weight:
376.66
Pathway:
Immunology/Inflammation; Microbiology/Virology; Metabolism; Endocrinology/Hormones
Purity:
0.98
SMILES:
CCCN(CCOc1c(Cl)cc(Cl)cc1Cl)C(=O)n1ccnc1
Target:
Estrogen Receptor/ERR; AhR; Androgen Receptor; Antifungal
References
1. Liu J, et al. Whole transcriptome analysis of Penicillium digitatum strains treatmented with prochloraz reveals their drug-resistant mechanisms. BMC Genomics. 2015 Oct 24;16:855.
2. Alpertunga B, et al. Effects of prochloraz on DNA damage, lipid peroxidation and antioxidant system in vitro. Toxicol Mech Methods. 2014 May;24(4):268-75.
3. Baumann L, et al. Prochloraz causes irreversible masculinization of zebrafish (Danio rerio). Environ Sci Pollut Res Int. 2015 Nov;22(21):16417-22.
4. Lundqvist J, et al. Fungicide prochloraz induces oxidative stress and DNA damage in vitro. Food Chem Toxicol. 2016 May;91:36-41.