ML204 hydrochloride
| Code | Size | Price |
|---|
| TAR-T24481-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24481-50mg | 50mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
ML204 is a potent inhibitor of the TRPC4 channel. ML204 inhibited TRPC4β-mediated intracellular Ca(2+) rise (IC50: 0.96 μM) and exhibited 19-fold selectivity against muscarinic receptor-coupled TRPC6 channel activation.
CAS:
2070015-10-8
Formula:
C15H19ClN2
Molecular Weight:
262.78
Purity:
0.98
SMILES:
Cl.Cc1cc(nc2ccccc12)N1CCCCC1
References
1. Lindstr?m JB, Pierce NT, Latz MI. Role of TRP Channels in Dinoflagellate Mechanotransduction. Biol Bull. 2017 Oct;233(2):151-167. doi: 10.1086/695421. Epub 2018 Jan 3. PubMed PMID: 29373067.
2. Wang X, Dande RR, Yu H, Samelko B, Miller RE, Altintas MM, Reiser J. TRPC5 Does Not Cause or Aggravate Glomerular Disease. J Am Soc Nephrol. 2018 Feb;29(2):409-415. doi: 10.1681/ASN.2017060682. Epub 2017 Oct 23. PubMed PMID: 29061651; PubMed Central PMCID: PMC5791075.
3. Maddox JW, Khorsandi N, Gleason E. TRPC5 is required for the NO-dependent increase in dendritic Ca(2+) and GABA release from chick retinal amacrine cells. J Neurophysiol. 2018 Jan 1;119(1):262-273. doi: 10.1152/jn.00500.2017. Epub 2017 Oct 4. PubMed PMID: 28978766.
4. Ilatovskaya DV, Palygin O, Levchenko V, Endres BT, Staruschenko A. The Role of Angiotensin II in Glomerular Volume Dynamics and Podocyte Calcium Handling. Sci Rep. 2017 Mar 22;7(1):299. doi: 10.1038/s41598-017-00406-2. PubMed PMID: 28331185; PubMed Central PMCID: PMC5428415.