IM-156 (acetate)
| Code | Size | Price |
|---|
| TAR-T36420-1mg | 1mg | £111.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
IM-156 is an inhibitor of mitochondrial complex I, also known as NADH dehydrogenase (IC50= 2.2 μM) and an activator of AMP-activated protein kinase α (AMPKα).1,2It reduces the oxygen consumption rate (OCR; IC50= 3.3 μM) and decreases mitochondrial ATP production in Eμ-Mycmouse lymphoma cells.1IM-156 (10, 30, and 50 μM) increases AMPKα activity in primary rat peritoneal mesothelial cells and protects against chlorhexidine-induced peritoneal fibrosis in rats when administered at a dose of 1 mg/kg.2It reduces tumor growth in an AT-84 murine oral cancer model and decreases age-related decline in novel object recognition, spatial working, and contextual memory in mice.3,4
CAS:
2043654-54-0
Formula:
C13H16F3N5O?XC2H4O2
Molecular Weight:
315.3
Purity:
0.98
SMILES:
FC(F)(OC1=CC=C(NC(NC(N2CCCC2)=N)=N)C=C1)F.CC(O)=O
References
Lam TG, et al. New metformin derivative HL156A prevents oral cancer progression by inhibiting the insulin-like growth factor/AKT/mammalian target of rapamycin pathways. Cancer Sci. 2018;109(3):699-709.
Izreig S, et al. Repression of LKB1 by miR-17?92 Sensitizes MYC-Dependent Lymphoma to Biguanide Treatment. Cell Rep Med. 2020;1(2):100014.
Ju KD, et al. HL156A, a novel AMP-activated protein kinase activator, is protective against peritoneal fibrosis in an in vivo and in vitro model of peritoneal fibrosis. Am J Physiol Renal Physiol. 2016;310(5):342-350.
Bang E, et al. The Improving Effect of HL271, a Chemical Derivative of Metformin, a Popular Drug for Type II Diabetes Mellitus, on Aging-induced Cognitive Decline. Exp Neurobiol. 2018;27(1):45-56.