Dimethyl fumarate
| Code | Size | Price |
|---|
| TAR-T0492-500mg | 500mg | £107.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Dimethyl fumarate, a fumarate derivative, is used as antiinflammatory and immunomodulatory agent.
CAS:
624-49-7
Formula:
C6H8O4
Molecular Weight:
144.126
Pathway:
Immunology/Inflammation; NF-κb; Proteases/Proteasome; Autophagy; Metabolism; Microbiology/Virology
Purity:
0.9051
SMILES:
COC(=O)C=CC(=O)OC
Target:
Reactive Oxygen Species; HIV Protease; Nrf2; Endogenous Metabolite; Autophagy
References
1. Albrecht P, et al. J Neuroinflammation,2012, 9, 163.
2. Peng H, et al. J Biol Chem,2012, 287(33), 282017-28026.
3. Meili-Butz S, et al. Eur J Pharmacol,2008, 586(1-3), 251-258.
4. Cross SA, et al. J Immunol,2011, 187(10), 52015-5025.
5. Jing X, et al. Neuroscience,2015, 286, 131-140.
6. Li Y, et al. Dimethyl fumarate accelerates wound healing under diabetic condition. J Mol Endocrinol. 2018 Jul 23. pii: JME-18-0102.
7. Wang Y, Ma H, Huang J, et al. Discovery of bardoxolone derivatives as novel orally active necroptosis inhibitors[J]. European Journal of Medicinal Chemistry. 2020: 113030.