Busulfan
Code | Size | Price |
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TAR-T0923-500mg | 500mg | £107.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T0923-1mL | 1 mL * 10 mM (in DMSO) | £111.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T0923-1g | 1g | £120.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
Busulfan is a synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood, busulfan appears to act through the alkylation of DNA. Following systemic absorption of busulfan, carbonium ions are formed, resulting in DNA alkylation and DNA breaks and inhibition of DNA replication and RNA transcription.
CAS:
55-98-1
Formula:
C6H14O6S2
Molecular Weight:
246.29
Pathway:
DNA Damage/DNA Repair; Apoptosis
Purity:
0.9977
SMILES:
CS(=O)(=O)OCCCCOS(C)(=O)=O
Target:
Apoptosis; DNA Alkylator/Crosslinker; DNA Alkylation
References
1. Meng A, et al. Cancer Res, 2003, 63(17), 5414-5419.
2. Probin V, et al. Free Radic Biol Med, 2007, 42(12), 1858-1865.
3. Choi YJ, et al. FEBS Lett, 2004, 575(1-3), 41-51.
4. Robert-Richard E, et al. Haematologica, 2006, 91(10), 1384.
5. Yeager AM, et al. Blood, 1991, 78(12), 3312-3316.