TargetMol

Lidorestat

Product Code:
 
TAR-T15756
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15756-5mg5mg£104.00
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TAR-T15756-1mL1 mL * 10 mM (in DMSO)£107.00
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TAR-T15756-10mg10mg£124.00
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TAR-T15756-50mg50mg£229.00
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This product comes from: United States.
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Further Information

Bioactivity:
Lidorestat is a selective and orally active aldose reductase inhibitor (IC50: 5 nM). Lidorestat improves nerve conduction and reduces cataract formation. It can be used for chronic diabetes complications.
CAS:
245116-90-9
Formula:
C18H11F3N2O2S
Molecular Weight:
376.35
Pathway:
Endocrinology/Hormones|Metabolism
Purity:
0.98
SMILES:
OC(=O)Cn1cc(Cc2nc3c(F)c(F)cc(F)c3s2)c2ccccc12
Target:
Reductase

References

1. Noh HL, et al. Regulation of plasma fructose and mortality in mice by the aldose reductase inhibitor lidorestat. J Pharmacol Exp Ther. 2009 Feb;328(2):496-503. 2. Van Zandt MC, et al. Discovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat) and congeners as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications. J Med Chem. 2005 May 5;48(9):3141-52. 3. Maccari R, et al. Identification of new non-carboxylic acid containing inhibitors of aldose reductase. Bioorg Med Chem. 2010 Jun 1;18(11):4049-55.