Doxifluridine
| Code | Size | Price |
|---|
| TAR-T1600-500mg | 500mg | £107.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T1600-1g | 1g | £124.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Doxifluridine is a fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridine, designed to circumvent the rapid degradation of 5-FU by dihydropyrimidine dehydrogenase in the gut wall, is converted into 5-FU in the presence of pyrimidine nucleoside phosphorylase. 5-FU interferes with DNA synthesis and subsequent cell division by reducing normal thymidine production and interferes with RNA transcription by competing with uridine triphosphate for incorporation into the RNA strand.
CAS:
3094-09-5
Formula:
C9H11FN2O5
Molecular Weight:
246.19
Pathway:
Cell Cycle/Checkpoint; DNA Damage/DNA Repair
Purity:
0.9996
SMILES:
[C@H]1(n2c(=O)[nH]c(=O)c(c2)F)[C@@H]([C@@H]([C@H](O1)C)O)O
Target:
Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis
References
1. Naganuma Y, et al. Cancer Sci,2011, 102(8), 1545-1552.
2. Berne M, et al. Cancer Invest,1988, 6(4), 377-383.
3. Baek IH, et al. Eur J Drug Metab Pharmacokinet,2013, 38(4), 295-299.
4. Yamamoto S, et al. Gan To Kagaku Ryoho,1999, 26(10), 1443-1448.
5. Konishi H, et al. J Pharm Pharmacol,2003, 55(1), 143-149.