Melatonin
| Code | Size | Price |
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| TAR-T1659-1g | 1g | £96.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Melatonin is a biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness and decreases during exposure to light. Melatonin is implicated in the regulation of SLEEP, mood, and REPRODUCTION. Melatonin is also an effective antioxidant.
CAS:
73-31-4
Formula:
C13H16N2O2
Molecular Weight:
232.283
Pathway:
Autophagy; GPCR/G Protein; Apoptosis; Metabolism; Endocrinology/Hormones; Neuroscience
Purity:
0.9979
SMILES:
COc1ccc2[nH]cc(CCNC(C)=O)c2c1
Target:
CaMK; Apoptosis; Mitophagy; Estrogen/progestogen Receptor; Melatonin Receptor; Glutathione Peroxidase; Endogenous Metabolite; ROR; Autophagy
References
1. Reiter RJ, et al. J Biomed Sci, 2000, 7(6), 444-458.
2. Reiter RJ, et al. Prog Neurobiol, 1998, 56(3), 359-384.
3. Reiter RJ, et al. Cell Biochem Biophys, 2001, 34(2), 237-256.
4. Vanecek J, et al. Physiol Rev, 1998, 78(3), 687-721.
5. Kilic U, et al. Particular phosphorylation of PI3K/Akt on Thr308 via PDK-1 and PTEN mediates melatonin's neuroprotective activity after focal cerebral ischemia in mice. Redox Biol. 2017 Apr 5;12:657-665.
6. Hu C, et al. Neuroprotective effect of melatonin on soluble A?1-42-induced cortical neurodegeneration via Reelin-Dab1 signaling pathway. Neurol Res. 2017 Apr 7:1-1
7. Rahim I, et al. Melatonin administration to wild-type mice and non-treated NLRP3 mutant mice share similar inhibition of the inflammatory response during sepsis. J Pineal Res. 2017 Mar 31
8. Bu LJ, et al. Melatonin, a novel selective ATF-6 inhibitor, induces human hepatoma cell apoptosis through COX-2 downregulation. World J Gastroenterol. 2017 Feb 14;23(6):986-998.