Thiamine disulfide
| Code | Size | Price |
|---|
| TAR-T20062-500mg | 500mg | £103.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T20062-1mL | 1 mL * 10 mM (in DMSO) | £107.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Thiamine, also known as thiamin or vitamin B1, is a vitamin found in food and manufactured as a dietary supplement and medication. Thiamine also acts as a cofactor for many centrally metabolizing enzymes.
CAS:
67-16-3
Formula:
C24H34N8O4S2
Molecular Weight:
562.71
Pathway:
Proteases/Proteasome; Microbiology/Virology; Metabolism
Purity:
0.9918
SMILES:
CC(N(Cc1cnc(C)nc1N)C=O)=C(CCO)SSC(CCO)=C(/C)N(Cc1cnc(C)nc1N)C=O
Target:
HIV Protease; Endogenous Metabolite
References
1. Xiao D, Meng FH, Dai W, Yong Z, Liu JQ, Zhou XB, Li S. Design, Synthesis and Biological Evaluation of Brain-Targeted Thiamine Disulfide Prodrugs of Ampakine Compound LCX001. Molecules. 2016 Apr 14;21(4):488. doi: 10.3390/molecules21040488. PubMed PMID: 27089316.
2. Volvert ML, Seyen S, Piette M, Evrard B, Gangolf M, Plumier JC, Bettendorff L. Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipid-soluble thiamine disulfide derivatives. BMC Pharmacol. 2008 Jun 12;8:10. doi: 10.1186/1471-2210-8-10. PubMed PMID: 18549472; PubMed Central PMCID: PMC2435522.
3. Parkhomenko IuM, Stepuro II, Donchenko GV, Stepuro VI. [Oxidized derivatives of thiamine: formation, properties, biological role]. Ukr Biokhim Zh (1999). 2012 Nov-Dec;84(6):5-24. Review. Russian. PubMed PMID: 23387265.
4. Stepuro II, Oparin AY, Stsiapura VI, Maskevich SA, Titov VY. Oxidation of thiamine on reaction with nitrogen dioxide generated by ferric myoglobin and hemoglobin in the presence of nitrite and hydrogen peroxide. Biochemistry (Mosc). 2012 Jan;77(1):41-55. doi: 10.1134/S0006297912010051. PubMed PMID: 22339632.