1,2,3,4,5,6-Hexabromocyclohexane
| Code | Size | Price |
|---|
| TAR-T22462-5mg | 5mg | £104.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T22462-50mg | 50mg | £222.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T22462-100mg | 100mg | £301.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
The compound effectively and directly inhibits JAK2 tyrosine kinase autophosphorylation and specifically inhibits ligand-dependent JAK2 activation. It has no cytotoxicity at 100 μM. A 16-hour treatment with compound (1 μM) decreases JAK2 tyrosine autophosphorylation levels to ~ 50% while 50 μM eliminates nearly all JAK2 activity.
CAS:
1837-91-8
Formula:
C6H6Br6
Molecular Weight:
557.538
Purity:
0.98
SMILES:
BrC1C(Br)C(Br)C(Br)C(Br)C1Br
References
1. Lee M, Rangisetty J B, Pullagurla M R, et al. 1-(1-Naphthyl) piperazine as a novel template for 5-HT 6 serotonin receptor ligands[J]. Bioorganic & medicinal chemistry letters, 2005, 15(6): 1707-1711.
2. Nichols D E, Nichols C D. Serotonin receptors[J]. Chemical reviews, 2008, 108(5): 1614-1641.
3. Cohen M L, Wittenauer L A. Relationship between serotonin and tryptamine receptors in the rat stomach fundus[J]. Journal of Pharmacology and Experimental Therapeutics, 1985, 233(1): 75-79.
4. McKearney J W. Serotonin-antagonist effects of 1-(1-naphthyl) piperazine on operant behavior of squirrel monkeys[J]. Neuropharmacology, 1989, 28(8): 817-821.