Fe-TMPyP
| Code | Size | Price |
|---|
| TAR-T27314-500mg | 500mg | £1,057.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Fe-TMPyP binds to the prion protein PrP and inhibits misfolding. Fe-TMPyP is also a peroxynitrite decomposition catalyst.
CAS:
133314-07-5
Formula:
C44H36Cl5FeN8
Molecular Weight:
909.92
Purity:
0.98
SMILES:
[Cl-].[Cl-].[Cl-].[Cl-].C[n+]1ccc(cc1)C1=C2C=CC3=[N+]2[Fe+3]24(Cl)n5c1ccc5C(=C1C=CC(C(c5cc[n+](C)cc5)=c5ccc(=C3c3cc[n+](C)cc3)n25)=[N+]41)c1cc[n+](C)cc1
References
1. Gupta AN, Neupane K, Rezajooei N, Cortez LM, Sim VL, Woodside MT. Pharmacological chaperone reshapes the energy landscape for folding and aggregation of the prion protein. Nat Commun. 2016 Jun 27;7:12058. doi: 10.1038/ncomms12058. PubMed PMID: 27346148; PubMed Central PMCID: PMC4931252.
2. Gao L, Chen X, Peng T, Yang D, Wang Q, Lv Z, Shen J. Caveolin-1 protects against hepatic ischemia/reperfusion injury through ameliorating peroxynitrite-mediated cell death. Free Radic Biol Med. 2016 Jun;95:209-15. doi: 10.1016/j.freeradbiomed.2016.03.023. Epub 2016 Mar 25. PubMed PMID: 27021966.
3. Imaizumi N, Kwang Lee K, Zhang C, Boelsterli UA. Mechanisms of cell death pathway activation following drug-induced inhibition of mitochondrial complex I. Redox Biol. 2015;4:279-88. doi: 10.1016/j.redox.2015.01.005. Epub 2015 Jan 16. PubMed PMID: 25625582; PubMed Central PMCID: PMC4315936.
4. Lee KK, Boelsterli UA. Bypassing the compromised mitochondrial electron transport with methylene blue alleviates efavirenz/isoniazid-induced oxidant stress and mitochondria-mediated cell death in mouse hepatocytes. Redox Biol. 2014;2:599-609. doi: 10.1016/j.redox.2014.03.003. Epub 2014 Mar 13. PubMed PMID: 25460728; PubMed Central PMCID: PMC4297936.