Cefsulodin (sodium salt hydrate)
| Code | Size | Price |
|---|
| TAR-T36600-500mg | 500mg | £258.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Cefsulodin is a β-lactam antibiotic that lyses actively-growingE. coliby binding specifically to the intermembrane proteins, penicillin-binding proteins 1a and b, whose transglycosylase and transpeptidase activities are involved in cell elongation and septation.1Cefsulodin has been used in combination with other β-lactam antibiotics, such as cefazolin as a strategy to circumvent drug resistance.2
CAS:
1426397-23-0
Formula:
C22H19N4O8S2?Na [XH2O]
Molecular Weight:
531.5
Purity:
0.98
SMILES:
O=C(N[C@@H]1C(N2[C@]1([H])SCC(C[N+]3=CC=C(C(N)=O)C=C3)=C2C([O-])=O)=O)[C@H](S([O-])(=O)=O)C4=CC=CC=C4.[Na+].O
References
Jacoby, G.H., and Young, K.D.Cell cycle-independent lysis of Escherichia coli by cefsulodin, an inhibitor of penicillin-binding proteins 1a and 1bJournal of Bacteriology173(1)1-5(1991)
Sarkar, S.K., Dutta, M., Kumar, A., et al.Sub-inhibitory cefsulodin sensitization of E. coli to ?-lactams is mediated by PBP1b inhibitionPLoS One7(11)(2012)