D-NAME (hydrochloride)
| Code | Size | Price |
|---|
| TAR-T36719-500mg | 500mg | £127.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Quantity:
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
N(G)-Nitro-D-arginine methyl ester (D-NAME) is the less active enantiomer of the nitric oxide (NO) synthase inhibitor N(G)-nitro-L-arginine methyl ester . D-NAME was initially thought to be inactive and was often used as a negative control for L-NAME. Later studies showed that D-NAME (40 mg/kg/day in rats) can have similar but less pronounced effects as L-NAME (40 mg/kg/day in rats) in the cardiovascular system, particularly at long-term timepoints. D-NAME (3-10 µg/mouse) had no effect on nociception in mice assessed using the tail flick test.
CAS:
50912-92-0
Formula:
C7H15N5O4
Molecular Weight:
233.228
Purity:
0.98
SMILES:
COC(=O)[C@H](N)CCCNC(=N)N[N+]([O-])=O
References
Palmer, R.M.J., Rees, D.D., Ashton, D.S., et al. L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation Biochem. Biophys. Res. Commun. 153(3), 1251-1256 (1988).
Bab?l, P., Pech?nov?, O., and Bern?tov?, I. Long-term administration of D-NAME induces hemodynamic and structural changes in the cardiovascular system Physiol. Res. 49(1), 47-54 (2000).
Kawabata, A., Umeda, N., and Takagaki, H. L-arginine exerts a dual role in nociceptive processing in the brain: Involvement of the kyotorphin-Met-enkephalin pathway and NO-cyclic GMP pathway Br. J. Pharmacol. 109(1), 73-79 (1993).
Chinellato, A., Froldi, G., Caparrota, L., et al. Pharmacological characterization of endothelial cell nitric oxide synthase inhibitors in isolated rabbit aorta Life Sci. 62(6), 479-490 (1998).