4-Phenylbutyric acid
| Code | Size | Price |
|---|
| TAR-T5886-500mg | 500mg | £103.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T5886-1mL | 1 mL * 10 mM (in DMSO) | £111.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Benzenebutyric acid is an inhibitor of HDAC,and is an antineoplastic agent.
CAS:
1821-12-1
Formula:
C10H12O2
Molecular Weight:
164.204
Pathway:
Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology
Purity:
0.9976
SMILES:
OC(=O)CCCc1ccccc1
Target:
Virus Protease; HDAC
References
Gon?alo Frouco, Freitas F B , Martins C , et al. Sodium phenylbutyrate abrogates African swine fever virus replication by disrupting the virus-induced hypoacetylation status of histone H3K9/K14[J]. Virus Research, 2017, 242:24-29.
Tsg-Hui C , Eva S . Enhanced growth inhibition by combination differentiation therapy with ligands of peroxisome proliferator-activated receptor-gamma and inhibitors of histone deacetylase in adenocarcinoma of the lung[J]. Clinical Cancer Research, 2002, 8(4):1206-1212.
Wang H, Chen J, Bai G, et al. mTOR Modulates the Endoplasmic Reticulum Stress-Induced CD4 + T Cell Apoptosis Mediated by ROS in Septic Immunosuppression. Mediators of Inflammation. 2022
Dong L, Xu M, Li Y, et al.SMURF1 attenuates endoplasmic reticulum stress by promoting the degradation of KEAP1 to activate NRF2 antioxidant pathway.Cell Death & Disease.2023, 14(6): 361.
Yu Y, Wu T, Zhang X, et al.Regorafenib activates oxidative stress by inhibiting SELENOS and potentiates oxaliplatin-induced cell death in colon cancer cells.European Journal of Pharmacology.2023: 175986.