Norepinephrine
| Code | Size | Price |
|---|
| TAR-T7044-100mg | 100mg | £103.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T7044-1mL | 1 mL * 10 mM (in DMSO) | £111.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Norepinephrine can stimulate apoptosis in adult rat ventricular myocytes by activation of the β-adrenergic pathway. It can up-regulate the expression of vascular endothelial growth factor, matrix metalloproteinase (MMP)-2, and MMP-9 in nasopharyngeal carcinoma tumour cells.
CAS:
51-41-2
Formula:
C8H11NO3
Molecular Weight:
169.18
Pathway:
Metabolism; Proteases/Proteasome; Neuroscience; GPCR/G Protein; Autophagy
Purity:
0.9966
SMILES:
NC[C@H](O)c1ccc(O)c(O)c1
Target:
MMP; Endogenous Metabolite; Adrenergic Receptor; Autophagy
References
Ngan Kee W D, et al. Randomized double-blinded comparison of norepinephrine and phenylephrine for maintenance of blood pressure during spinal anesthesia for cesarean delivery.[J]. Anesthesiology, 2015, 122(4):736-745.
Gu Y, Zhang M, Liu X, et al Impact of bilateral sympathetic stellate ganglionectomy on TGF-?1 signaling pathway in rats with chronic volume overload. Frontiers in Physiology. 2020, 11: 375
Communal C, et al. Norepinephrine Stimulates Apoptosis in Adult Rat Ventricular Myocytes by Activation of the ?-Adrenergic Pathway[J]. Circulation, 1998, 98(13):1329-1334.
Wang H, Wu Y, Zou Q, et al. A biosensing system using a multiparameter nonlinear dynamic analysis of cardiomyocyte beating for drug-induced arrhythmia recognition. Microsystems & Nanoengineering. 2022, 8(1): 1-14
Gu Y, Zhang M, Liu X, et al. Impact of bilateral sympathetic stellate ganglionectomy on TGF-?1 signaling pathway in rats with chronic volume overload[J]. Frontiers in Physiology. 2020, 11: 375.
Mansley M K, et al. Norepinephrine stimulates the epithelial sodium channel (ENaC) in cortical collecting duct cells via ?2-adrenoceptors[J]. Am J Physiol Renal Physiol, 2015, 308(5):F450.
Chen H, Cao N, Wang L, et al. Biased activation of ?2-AR/Gi/GRK2 signal pathway attenuated ?1-AR sustained activation induced by ?1-adrenergic receptor autoantibody. Cell death discovery,. 2021, 7(1): 1-11.
Wang Y, Wang X, Wang K, et al.Chronic stress accelerates glioblastoma progression via DRD2/ERK/?-catenin axis and Dopamine/ERK/TH positive feedback loop.Journal of Experimental & Clinical Cancer Research.2023, 42(1): 1-17.