Valproic Acid
| Code | Size | Price |
|---|
| TAR-T7064-1mL | 1 mL * 10 mM (in DMSO) | £111.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T7064-1g | 1g | £111.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Valproic Acid is a branched chain fatty acid which potentially enhances central GABAergic neurotransmission and inhibits Na+ channels. Currently, the various molecular mechanisms of action of Valproic Acid have not been completely elucidated. Valproic Acid has been reported to be a potent inhibitor of histone deacetylases (HDACs) in vitro. Valproic Acid is also noted to relieve HDAC-dependent transcriptional repression and causes the hyperacetylation of histones in cultured cells. Additionally, Valproic Acid is reported to activate Wnt-dependent gene expression and to mimic trichostatin A (sc-3511) in the inhibition of histone deacetylase.
CAS:
99-66-1
Formula:
C8H16O2
Molecular Weight:
144.214
Pathway:
Chromatin/Epigenetic; Autophagy; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Proteases/Proteasome; Stem Cells
Purity:
0.99
SMILES:
CCCC(CCC)C(O)=O
Target:
Mitophagy; Gamma-secretase; HIV Protease; GABA Receptor; Sodium Channel; HDAC; Autophagy
References
Han L, Song B, Zhang P, et al.PC3T: a signature-driven predictor of chemical compounds for cellular transition.Communications Biology.2023, 6(1): 989.
Zhu Z A, Li Y Y, Xu J, et al.CDKL5 deficiency in adult glutamatergic neurons alters synaptic activity and causes spontaneous seizures via TrkB signaling.Cell Reports.2023, 42(10).
Paschoa O E D, et al. Modelling of the pharmacodynamic interaction between phenytoin and sodium valproate[J]. British Journal of Pharmacology, 2010, 125(7):1610-1616.
Tunnicliff G. Actions of sodium valproate on the central nervous system[J]. Journal of Physiology & Pharmacology An Official Journal of the Polish Physiological Society, 1999, 50(3):347.
G?ttlicher M, et al. Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells[J]. EMBO J. 2001 Dec 17;20(24):6969-78.