Rafoxanide
Code | Size | Price |
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TAR-T7093-1mL | 1 mL * 10 mM (in DMSO) | £111.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T7093-500mg | 500mg | £114.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T7093-1g | 1g | £139.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
Rafoxanide as a dual CDK4/6 inhibitor for the treatment of skin cancer. Rafoxanide is a salicylanilide used as an anthelmintic. It is used to treat fluke, hookworm and other infestations.
CAS:
22662-39-1
Formula:
C19H11Cl2I2NO3
Molecular Weight:
626.01
Pathway:
Cell Cycle/Checkpoint; Microbiology/Virology
Purity:
1
SMILES:
Oc1c(I)cc(I)cc1C(=O)Nc1ccc(Oc2ccc(Cl)cc2)c(Cl)c1
Target:
CDK; Parasite
References
Shi X, Li H, Shi A et al.Discovery of rafoxanide as a dual CDK4/6 inhibitor for the treatment of skin cancer[J].Oncol Rep. 2018 Sep;40(3):1592-1600.
Xiao W , Xu Z , Chang S , et al. Rafoxanide, an organohalogen drug, triggers apoptosis and cell cycle arrest in multiple myeloma by enhancing DNA damage responses and suppressing the p38 MAPK pathway[J]. Cancer Letters, 2019, 444:45-59.