anti-DDIT3 (DNA Damage-inducible Transcript 3 Protein) Rabbit Monoclonal (RM485)
| Code | Size | Price |
|---|
| REV-31-1377-00-R100 | 100 ul | £455.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit IgG
Antibody Clonality: Recombinant Antibody
Antibody Clone: RM485
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Shipping:
BLUE ICE
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
DNA Damage-inducible Transcript 3 Protein; C/EBP-homologous Protein 10; CHOP-10; GADD153
Concentration:
N/A
EClass:
32160000
Form (Short):
liquid
Formulation:
Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
Handling Advice:
Avoid freeze/thaw cycles.
Immunogen:
A peptide corresponding to the N-terminus of human DDIT3 (DNA damage-inducible transcript 3 protein).
Long Description:
Recombinant Antibody. This antibody reacts to human DDIT3 (DNA damage-inducible transcript 3 protein). Source: Rabbit. Isotype: Rabbit IgG. Immunogen: A peptide corresponding to the N-terminus of human DDIT3 (DNA damage-inducible transcript 3 protein). Applications: WB. DDIT3 [GADD153] is a small nuclear protein that is capable of dimerizing with transcription factors C/EBP alpha and beta. Once dimerized, this complex inhibits the normal binding and function of C/EBP to classical binding sites. Inversely, the C/EBP DDIT3 dimer gains binding activity to other non classical C/EBP stress related targets. Under normal cellular conditions this protein is not expressed in detectable levels, but is highly unregulated during times of cellular/ER stress. Examples of DDIT3 inducing stress include: treatment with tunicamycin, nutrient starvation and reducing agents that interfere with the calcium flux across the ER membrane. DDIT3 is a multifunctional transcription factor in endoplasmic reticulum (ER) stress response that plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress.
NCBI, Uniprot Number:
P35638
Package Type:
Vial
Product Description:
DDIT3 [GADD153] is a small nuclear protein that is capable of dimerizing with transcription factors C/EBP alpha and beta. Once dimerized, this complex inhibits the normal binding and function of C/EBP to classical binding sites. Inversely, the C/EBP DDIT3 dimer gains binding activity to other non classical C/EBP stress related targets. Under normal cellular conditions this protein is not expressed in detectable levels, but is highly unregulated during times of cellular/ER stress. Examples of DDIT3 inducing stress include: treatment with tunicamycin, nutrient starvation and reducing agents that interfere with the calcium flux across the ER membrane. DDIT3 is a multifunctional transcription factor in endoplasmic reticulum (ER) stress response that plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress.
Purity:
Protein A purified.
Source / Host:
Rabbit
Specificity:
This antibody reacts to human DDIT3 (DNA damage-inducible transcript 3 protein).
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibodies
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.