anti-TIA1 (Cytotoxic Granule Associated RNA Binding Protein TIA1) (T-cell-restricted Intracellular Antigen-1) Rabbit Monoclonal (RM490)
| Code | Size | Price |
|---|
| REV-31-1382-00-R100 | 100 ul | £455.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit IgG
Antibody Clonality: Recombinant Antibody
Antibody Clone: RM490
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Shipping:
BLUE ICE
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
T-cell-restricted Intracellular Antigen-1; Cytotoxic Granule Associated RNA-binding Protein TIA1
Concentration:
N/A
EClass:
32160000
Form (Short):
liquid
Formulation:
Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
Handling Advice:
Avoid freeze/thaw cycles.
Immunogen:
A peptide corresponding to the C-terminus of human TIA1.
Long Description:
Recombinant Antibody. This antibody reacts to human TIA-1. Source: Rabbit. Isotype: Rabbit IgG. Immunogen: A peptide corresponding to the C-terminus of human TIA1. Applications: WB. TIA1, also named as p40-TIA-1, is involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). It possesses nucleolytic activity against cytotoxic lymphocyte target cells. TIA1 may be involved in apoptosis. Similar to the ALS-related disease proteins TDP-43, hnRNPA1, and FUS, TIA1 is an RNA-binding protein containing a prionlike LCD and assembles into membrane-less organelles, including SGs. TIA1 mutations significantly increased the propensity of TIA1 protein to undergo phase transition. In live cells,TIA1 mutations delayed stress granule (SG) disassembly and promoted the accumulation of non-dynamic SGs that harbored TDP-43.
NCBI, Uniprot Number:
P31483
Package Type:
Vial
Product Description:
TIA1, also named as p40-TIA-1, is involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). It possesses nucleolytic activity against cytotoxic lymphocyte target cells. TIA1 may be involved in apoptosis. Similar to the ALS-related disease proteins TDP-43, hnRNPA1, and FUS, TIA1 is an RNA-binding protein containing a prionlike LCD and assembles into membrane-less organelles, including SGs. TIA1 mutations significantly increased the propensity of TIA1 protein to undergo phase transition. In live cells,TIA1 mutations delayed stress granule (SG) disassembly and promoted the accumulation of non-dynamic SGs that harbored TDP-43.
Purity:
Protein A purified.
Source / Host:
Rabbit
Specificity:
This antibody reacts to human TIA-1.
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibodies
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.