anti-Phospho-ULk1 (Autophagy-related Protein 1 Homolog ATG1) (Ser757) Rabbit Monoclonal (RM488)

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RevMab Biosciences
Product Code: REV-31-1380-00
Product Group: Primary Antibodies
CodeSizePrice
REV-31-1380-00-R100100 ul£455.00
Quantity:
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Overview

Host Type: Rabbit
Antibody Isotype: Rabbit IgG
Antibody Clonality: Recombinant Antibody
Antibody Clone: RM488
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Application: Western Blot (WB)
Shipping:
BLUE ICE
Storage:
-20°C

Images

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Western Blot of the lysates of A431 cells nontreated (-) or treated (+) with Calyculin A/Okadaic Acid, using Anti-Phospho-ULK1 (Ser757) rabbit monoclonal antibody (clone RM488) at a 1:1000 dilution.
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Western Blot of the lysates of A431 cells nontreated (-) or treated (+) with Calyculin A/Okadaic Acid, using Anti-Phospho-ULK1 (Ser757) rabbit monoclonal antibody (clone RM488) at a 1:1000 dilution.

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Further Information

Alternate Names/Synonyms:
Unc-51-like Kinase 1; Autophagy-related Protein 1; ATG1
Concentration:
N/A
EClass:
32160000
Form (Short):
liquid
Formulation:
Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
Handling Advice:
Avoid freeze/thaw cycles.
Immunogen:
A phospho-peptide corresponding to human phospho-ULK1 (Ser757).
Long Description:
Recombinant Antibody. This antibody reacts to human ULK1 only when phosphorylated at Ser757. There is no cross-reactivity to ULK1 that is not phosphorylated. This antibody may also react to mouse or rat Phospho-ULK1 (Ser757) as predicted by immunogen homology. Source: Rabbit. Isotype: Rabbit IgG. Immunogen: A phospho-peptide corresponding to human phospho-ULK1 (Ser757). Applications: WB. ULK1, also known as ATG1, is a key serine/threonine protein kinase probably acting at the most upstream step of autophagosome formation. Knockout of ULK1 results in a severe defect in the autophagy pathway. ULK1 is highly conserved among eukaryotes, and are the Unc-51-like kinases, ULK1 and ULK2 in mammals. ULK1 is ubiquitously expressed and involved in autophagy in response to starvation. It is the target of the TOR kinase signaling pathway that regulates autophagy through the control of phosphorylation status of ATG13. ULK1 also plays a role early in neuronal differentiation.
NCBI, Uniprot Number:
O75385
Package Type:
Vial
Product Description:
ULK1, also known as ATG1, is a key serine/threonine protein kinase probably acting at the most upstream step of autophagosome formation. Knockout of ULK1 results in a severe defect in the autophagy pathway. ULK1 is highly conserved among eukaryotes, and are the Unc-51-like kinases, ULK1 and ULK2 in mammals. ULK1 is ubiquitously expressed and involved in autophagy in response to starvation. It is the target of the TOR kinase signaling pathway that regulates autophagy through the control of phosphorylation status of ATG13. ULK1 also plays a role early in neuronal differentiation.
Purity:
Protein A purified.
Source / Host:
Rabbit
Specificity:
This antibody reacts to human ULK1 only when phosphorylated at Ser757. There is no cross-reactivity to ULK1 that is not phosphorylated. This antibody may also react to mouse or rat Phospho-ULK1 (Ser757) as predicted by immunogen homology.
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibodies
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.