Lac-Phe . acetate [N-Lactoyl-L-phenylalanine]
| Code | Size | Price |
|---|
| AG-CR1-3545-M010 | 10 mg | £130.00 |
Quantity:
| AG-CR1-3545-M050 | 50 mg | £490.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
Short term: +4°C. Long term: -20°C
Documents
Further Information
Alternate Names/Synonyms:
N-Lactoyl-L-phenylalanine
Appearance:
White to off-white powder.
CAS:
183241-73-8
EClass:
32160000
Form (Short):
solid
Handling Advice:
Keep cool and dry. Protect from light and moisture.
InChi:
InChI=1S/C12H15NO4.C2H4O2/c1-8(14)11(15)13-10(12(16)17)7-9-5-3-2-4-6-9;1-2(3)4/h2-6,8,10,14H,7H2,1H3,(H,13,15)(H,16,17);1H3,(H,3,4)/p-1/t8-,10-;/m0./s1
InChiKey:
TXEKHKMVDUMVBF-GNAZCLTHSA-M
Long Description:
Chemical. CAS: 183241-73-8. Formula: C12H15NO4 . C2H3O2. MW: 237.3 . 59.0. Lac-Phe is an exercise-inducible metabolite, also called exerkine, that suppresses feeding and obesity. Lac-Phe is increased heavily with exercise in mammals and acts to reduce food intake and potentially decrease overall body weight and fat mass. In diet-induced obese mice, pharmacological administration of Lac-Phe led to decreased food intake, adiposity and body weight, as well as improved glucose homeostasis, while movement and energy expenditure were not affected. The biosynthesis of Lac-Phe from lactate and phenylalanine occurs in CNDP2+ cells, including macrophages, monocytes and other immune and epithelial cells.
Molecular Formula:
C12H15NO4 . C2H3O2
Molecular Weight:
237.3 . 59.0
Package Type:
Vial
Product Description:
Lac-Phe is an exercise-inducible metabolite, also called exerkine, that suppresses feeding and obesity. Lac-Phe is increased heavily with exercise in mammals and acts to reduce food intake and potentially decrease overall body weight and fat mass. In diet-induced obese mice, pharmacological administration of Lac-Phe led to decreased food intake, adiposity and body weight, as well as improved glucose homeostasis, while movement and energy expenditure were not affected. The biosynthesis of Lac-Phe from lactate and phenylalanine occurs in CNDP2+ cells, including macrophages, monocytes and other immune and epithelial cells.
Product Line Areas NEW:
Biochemicals, Immunology, Immunometabolism, Metabolism, Obesity
Product Type:
Chemical
Purity:
>95% (HPLC)
SMILES:
C[C@H](O)C(N[C@@H](CC1=CC=CC=C1)C(O)=O)=O.CC([O-2])=O
Solubility Chemicals:
Soluble in water.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20A°C.
References
An exercise-inducible metabolite that suppresses feeding and obesity: V.L. Li, et al.; Nature 606, 785 (2022) | Exerkines in health, resilience and disease: L.S. Chow, et al.; Nature Review Endocrinol. 18, 273 (2022) | An exercise-induced metabolite alters feeding: C. Greenhill: Nature Review Endocrinol. 18, 521 (2022)