SARS-CoV-2 (COVID-19) S protein RBD antibody [F3C10]
| Code | Size | Price |
|---|
| PSI-31-547-0.1mg | 0.1mg | £657.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: F3C10
Regulatory Status: RUO
Target Species: SARS-CoV-2
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunocytochemistry (ICC)
- Western Blot (WB)
Shipping:
Blue Ice
Storage:
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 ˚C for 1-2 weeks. Store at -20 ˚C for 12 months. Store at -80 ˚C for long term storage.
Documents
Further Information
Additional Names:
S glycoprotein,E2,Peplomer protein,Spike protein S1
Application Note:
WB:1:1000 - 1:3000; ELISA:1:1000-1:3000; ICC:1:1000.
Background:
Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, CEACAM etc.. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
Buffer:
PBS, pH7.4, containing 0.05% proclin300, 50% glycerol.
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
Recombinant SARS-CoV-2 S Protein RBD. This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant SARS-CoV-2(2019-nCoV) RBD protein.
NCBI Gene ID #:
43740568
NCBI Official Name:
surface glycoprotein
NCBI Official Symbol:
S
NCBI Organism:
SARS-CoV-2
Physical State:
Liquid
Protein Accession #:
P0DTC2
Research Area:
Infectious Disease,COVID-19
Specificity:
Recognizes SARS-CoV-2 S Protein RBD
Swissprot #:
P0DTC2
User NOte:
Optimal dilutions for each application to be determined by the researcher.