Leupeptin . Hemisulfate
| Code | Size | Price |
|---|
| PSI-21-803-100mg | 100mg | £638.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Room Temp
Storage:
Short Term Storage: +4C. Long Term Storage: -20C. Handling Advice: Keep cool and dry. Protect from light and moisture. Use/Stability: Stable for at least 2 years after receipt when stored at -20C.
Documents
Further Information
Additional Names:
Acetyl-L-leucyl-L-leucyl-L-argininal . Hemisulfate
Background:
Potent, competitive and reversible cysteine, serine and threonine protease inhibitor. Inhibits calpain, kallikrein, trypsin, plasmin, papain and cathepsin B.
Does not inhibit pepsin, elastase, renin, cathepsins A and D, thrombin or α-chymotrypsin.
Used to protect against hearing loss caused by acoustic overstimulation or the ototoxic antibiotic gentamicin.
Shown to inhibit activation-induced programmed cell death.
Antioxidant and anti-inflammatory agent.
Widely used as a protein purification tool to prevent proteases present in tissue samples from degrading the protein of interest.
Molecular docking and molecular dynamics simulation of leupeptin with the transmembrane serine protease TMPRSS2, show strong interactions with the key amino acids Ser186, His41 and Asp180 of catalytic triad present in the active site of TMPRSS2. This interaction causes the inhibition of the function of TMPRSS2, which is essential for SARS-CoV-2 viral entry and infection. As an inhibitor of TMPRSS2 this agent could be repurposed for treatment of COVID-19.
CAS:
103476-89-7
Formula:
C20H38N6O4 . 0.5 H2SO4
InChi Key:
CIPMKIHUGVGQTG-VFFZMTJFSA-N
Merck Index:
4.37222222222222
Physical State:
Lyophilized
Predicted Molecular Weight:
426.6 . 49.0/ Sequence: Ac-Leu-Leu-Arginal
Purity:
greater than or equal to 97% (HPLC)
Smiles:
OS(O)(=O)=O.[H]C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O.[H]C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O
Solubility:
Soluble in ethanol, methanol or water.