FAS recombinant monoclonal antibody, clone R-125224
| Code | Size | Price |
|---|
| RAB01166-200ug | 200 ug | £709.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Antibody Isotype: IgG, Kappa
Antibody Clonality: Recombinant Antibody
Antibody Clone: R-125224
Regulatory Status: RUO
Target Species: Human
Storage:
Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
Further Information
Antigen Target Species:
Human
Form:
Liquid
Gene Alias:
ALPS1A|APO-1|APT1|CD95|FAS1|FASTM|TNFRSF6
Gene Description:
Fas (TNF receptor superfamily, member 6)
Gene ID:
355
Gene Name:
FAS
Immunogen:
Original antibody is raised against by the humanization of the murine HFE7A anti-Fas antibody by grafting the CDR regions to the framework regions of the human 8E10 antibody and substituting key framework residues from the murine antibody into the 8E10 se
Product Description:
Recombinant rabbit monoclonal antibody raised against human R-125224.
Recommended Dilutions:
Flow cytometry
Immunofluorescence
Western Blot
The optimal working dilution should be determined by the end user.
Immunofluorescence
Western Blot
The optimal working dilution should be determined by the end user.
Specificity:
R-125224 binds to the extracellular portion of human Fas at an eptiope consisting of the sequence RTQNTKCRCK (aa 105-114) (pmid: 11754745). Fas is a type I membrane protein which belongs to the tumor necrosis factor (TNF) receptor/nerve growth factor (NGF) receptor superfamily. It is able to transduce apoptotic signals into the cell when bound by its ligand FasL (Fas ligand), which is primarily expressed in activated T lymphoid-myeloid lineage cells, in the eye, in reproductive organs and in some tumors. The Fas-FasL system is known to play an important role in maintaining the immune system as mice with Fas-defective lymphoproliferation (lpr) and FasL-defective generalized lymphoproliferative disease (gld) mutations develop massive lymphadenopathy and autoimmune diseases.
Storage Buffer:
In PBS with 0.02% Proclin 300.