anti-Periostin mAb (blocking) (OC-20) (preservative free)

Osteoblast-specific Factor 2; OSF-2; Postn

Lot dependent

32160000

liquid

Sterile liquid. In 20mM sodium phosphate buffer, pH7.6 containing 150mM sodium chloride.

After opening, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.

Recombinant fragments of human periostin.

Monoclonal Antibody. Recognizes human and mouse periostin. Detects the FAS1-2 domain of periostin at a new binding site for the integrins alphavbeta3 and alphavbeta5. Isotype: Mouse IgMkappa. Clone: OC-20. Applications: FUNC (Blocking), ICC. Liquid. In 20mM sodium phosphate buffer, pH7.6 containing 150mM sodium chloride. Periostin is a 90-kDa matricellular protein that consists of a typical signal sequence, followed by a cysteine-rich region, an EMI domain (protein-protein interactions), four tandem fasciclin-like domains that are responsible for integrin binding, and a C-terminal region. Periostin was originally isolated as an osteoblast-specific factor that functions as a cell adhesion molecule for pre-osteoblasts and in osteoblast recruitment, attachment and spreading. Periostin is also involved in many fundamental biological processes such as cell proliferation, cell invasion and angiogenesis. Periostin expression is increased by both transforming growth factor beta1 (TGF-beta1) and bone morphogenetic protein 2 (BMP-2). Changes in periostin expression are commonly detected in various cancers and pre-cancerous conditions, and periostin may be involved in regulating cancer cell activities that contribute to tumorigenesis, cancer progression and metastasis. Periostin has shown to be involved in many aspects of allergic inflammation, such as eosinophil recruitment, airway remodeling, development of a Th2 phenotype and increased expression of inflammatory mediators. It is evaluated as a biomarker for bronchial asthma and airway inflammation.

Plastic Vial

Periostin is a 90-kDa matricellular protein that consists of a typical signal sequence, followed by a cysteine-rich region, an EMI domain (protein-protein interactions), four tandem fasciclin-like domains that are responsible for integrin binding, and a C-terminal region. Periostin was originally isolated as an osteoblast-specific factor that functions as a cell adhesion molecule for pre-osteoblasts and in osteoblast recruitment, attachment and spreading. Periostin is also involved in many fundamental biological processes such as cell proliferation, cell invasion and angiogenesis. Periostin expression is increased by both transforming growth factor beta1 (TGF-beta1) and bone morphogenetic protein 2 (BMP-2). Changes in periostin expression are commonly detected in various cancers and pre-cancerous conditions, and periostin may be involved in regulating cancer cell activities that contribute to tumorigenesis, cancer progression and metastasis. Periostin has shown to be involved in many aspects of allergic inflammation, such as eosinophil recruitment, airway remodeling, development of a Th2 phenotype and increased expression of inflammatory mediators. It is evaluated as a biomarker for bronchial asthma and airway inflammation.

Cancer, Immunology, Inflammation, Antibodies

>95% (SDS-PAGE)

Purified from concentrated hybridoma tissue culture supernatant.

Recognizes human and mouse periostin. Detects the FAS1-2 domain of periostin at a new binding site for the integrins alphavbeta3 and alphavbeta5.

Non-hazardous

Primary Antibodies

12352203

Stable for at least 1 year after receipt when stored at -20°C.