VSTM5 (mouse):Fc (mouse) (rec.) (non-lytic)

V-set and Transmembrane Domain-containing Protein 5

1mg/ml after reconstitution.

32160000

<0.01EU/ug purified protein (LAL test).

solid

Lyophilized. Contains PBS.

After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution.

Recombinant protein. The extracellular domain of mouse VSTM5 (aa 28-146) is fused to the N-terminus of the mouse Fc IgG2a (non-lytic mutant). Source: CHO cells. Lyophilized. Contains PBS. The V-set and transmembrane domain-containing protein (VSTM) family is composed of 8 proteins: VSTM1v1, VSTM1v2, VSTM2a, VSTM2b, VSTM2L, VSTM3, VSTM4 and VSTM 5. Members of the VSTM family are associated with the regulation of functions of immune cells, adipose cells and neuronal cells. The VSTM family is an immunoglobulin (Ig) superfamily that shares structural similarities with the B7-like transmembrane proteins involved in immune regulation. VSTM1 and VSTM4 play positive and negative roles in macrophage activation, respectively. VSTM3 (TIGIT) acts as a co-inhibitory receptor that suppresses the cytokine production of T cells and NK cells. V-set and transmembrane domain-containing protein 5 (Vstm5), a newly characterized small membrane glycoprotein highly expressed in the CNS, facilitates the formation of neuronal dendrites and protrusions such as dendritic filopodia. Regulatory roles of VSTM5 for in vitro and in vivo immune responses have been reported. VSTM5 functions as a novel immune checkpoint by regulating T cell proliferation and cytokine production, Treg generation by maintenance of T cell energy and possibly induction of T cell apoptosis.

~60kDa (SDS-PAGE)

Q9D806

Plastic Vial

The V-set and transmembrane domain-containing protein (VSTM) family is composed of 8 proteins: VSTM1v1, VSTM1v2, VSTM2a, VSTM2b, VSTM2L, VSTM3, VSTM4 and VSTM 5. Members of the VSTM family are associated with the regulation of functions of immune cells, adipose cells and neuronal cells. The VSTM family is an immunoglobulin (Ig) superfamily that shares structural similarities with the B7-like transmembrane proteins involved in immune regulation. VSTM1 and VSTM4 play positive and negative roles in macrophage activation, respectively. VSTM3 (TIGIT) acts as a co-inhibitory receptor that suppresses the cytokine production of T cells and NK cells. V-set and transmembrane domain-containing protein 5 (Vstm5), a newly characterized small membrane glycoprotein highly expressed in the CNS, facilitates the formation of neuronal dendrites and protrusions such as dendritic filopodia. Regulatory roles of VSTM5 for in vitro and in vivo immune responses have been reported. VSTM5 functions as a novel immune checkpoint by regulating T cell proliferation and cytokine production, Treg generation by maintenance of T cell energy and possibly induction of T cell apoptosis.

>95% (SDS-PAGE)

The extracellular domain of mouse VSTM5 (aa 28-146) is fused to the N-terminus of the mouse Fc IgG2a (non-lytic mutant).

CHO cells

Fc

Non-hazardous

12352202

Stable for at least 6 months after receipt when stored at -20°C.Working aliquots are stable for up to 3 months when stored at -20°C.