m-3M3FBS
| Code | Size | Price |
|---|
| AG-CR1-3548-M010 | 10 mg | £85.00 |
Quantity:
| AG-CR1-3548-M050 | 50 mg | £310.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
Short term storage:+4°C. Long term storage:-20°C.
Further Information
Alternate Names/Synonyms:
2,4,6-Trimethyl-N-[3-(trifluoromethyl)phenyl]-benzenesulfonamide
Appearance:
White to off-white solid.
CAS:
200933-14-8
EClass:
32160000
Form (Short):
solid
GHS Symbol:
GHS07
Handling Advice:
Keep cool and dry. Protect from light. Protect from moisture.
Hazards:
H315, H319, H335
InChi:
ZIIUUSVHCHPIQD-UHFFFAOYSA-N
InChiKey:
InChI=1S/C16H16F3NO2S/c1-10-7-11(2)15(12(3)8-10)23(21,22)20-14-6-4-5-13(9-14)16(17,18)19/h4-9,20H,1-3H3
Long Description:
Chemical. CAS: 200933-14-8. Formula: C16H16F3NO2S. MW: 343.4. m-3M3FBS is a cell permeable and specific activator of phospholipase C (PLC) that has been shown to stimulate the PLC-mediated intracellular Ca2+ release, inositol phosphates production and superoxide generation in various cell types. It activates all PLC isotypes (beta2, beta3, gamma1, gamma2 and delta1) in vitro, but not heterotrimeric G proteins, PI 3-kinase or PLD. m-3M3FBS also affects calcium homeostasis independently of PLC activation. m-3M3FBS induces apoptosis in tumor cells through caspase activation, down-regulation of XIAP and intracellular calcium signaling. m-3M3FBS has been shown in vitro to trigger mitochondrial damage and activate NLRP10 (a bona fide inflammasome binding to Asc and Caspase-1) in keratinocytes. NLRP10 acts also as inflammasome in intestine epithelial cells and protects against autoinflammation in the gut.
MDL:
MFCD00095824
Molecular Formula:
C16H16F3NO2S
Molecular Weight:
343.4
Package Type:
Vial
Precautions:
P261, P280, P302+P352, P305+P351+P338, P304+P340, P405
Product Description:
m-3M3FBS is a cell permeable and specific activator of phospholipase C (PLC) that has been shown to stimulate the PLC-mediated intracellular Ca2+ release, inositol phosphates production and superoxide generation in various cell types. It activates all PLC isotypes (beta2, beta3, gamma1, gamma2 and delta1) in vitro, but not heterotrimeric G proteins, PI 3-kinase or PLD. m-3M3FBS also affects calcium homeostasis independently of PLC activation. m-3M3FBS induces apoptosis in tumor cells through caspase activation, down-regulation of XIAP and intracellular calcium signaling. m-3M3FBS has been shown in vitro to trigger mitochondrial damage and activate NLRP10 (a bona fide inflammasome binding to Asc and Caspase-1) in keratinocytes. NLRP10 acts also as inflammasome in intestine epithelial cells and protects against autoinflammation in the gut.
Purity:
>98%
Signal word:
Warning
SMILES:
FC(F)(F)C1=CC=CC(NS(C2=C(C)C=C(C)C=C2C)(=O)=O)=C1
Solubility Chemicals:
Soluble in DMSO (10mg/ml) or ethanol (10mg/ml).
Transportation:
Non-hazardous
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Identification of a Compound That Directly Stimulates Phospholipase C Activity: Y-S. Bae, et al.; Mol. Pharmacol. 63, 1043 (2003) | Phospholipase C activator m-3M3FBS affects Ca2+ homeostasis independently of phospholipase C activation: J. Krjukova, et al.; Br. J. Pharmacol. 143, 3 (2004) | The novel phospholipase C activator, m-3M3FBS, induces monocytic leukemia cell apoptosis: Y.-N. Lee, et al.; Cancer Lett. 222, 227 (2005) | The novel phospholipase C activator, m-3M3FBS, induces apoptosis in tumor cells through caspase activation, down-regulation of XIAP and intracellular calcium signaling: E.M. Jung, et al.; Apoptosis 13, 133 (2008) | Phospholipase C activator m-3M3FBS protects against morbidity and mortality associated with sepsis: S.D. Kim, et al.; J. Immunol. 189, 2000 (2012) | Increases in intracellular calcium via activation of potentially multiple phospholipase C isozymes in mouse olfactory neurons: S.A. Szebenyi, et al.; Front. Cell. Neurosci. 8, 336 (2014) | Effect of 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzene-sulfonamide on calcium influx in three contraction models: E. Grzesk, et al.; Biomed. Rep. 4, 117 (2016) | Ca2+-mediated mitochondrial inner membrane permeabilization induces cell death independently of Bax and Bak: G. Quarato, et al.; Cell Death Differ. 29, 1318 (2022) | Mitochondrial damage activates the NLRP10 inflammasome: T. Prochnicki, et al.; Nature Immunol. 24, 595 (2023) | Epithelial Nlrp10 inflammasome mediates protection against intestinal autoinflammation: D. Zheng, et al.; Nature Immunol. 24, 585 (2023)