Resorufin pentyl ether
| Code | Size | Price |
|---|
| CDX-R0015-M001 | 1 mg | £138.00 |
Quantity:
| CDX-R0015-M005 | 5 mg | £445.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
AMBIENT
Storage:
Short term storage:+4°C. Long term storage:-20°C.
Documents
Further Information
Alternate Names/Synonyms:
Pentoxyresorufin; 7-Pentoxyresorufin; O7-Pentylresorufin
Appearance:
Orange to red powder.
CAS:
87687-03-4
EClass:
32160000
Form (Short):
solid
GHS Symbol:
GHS07
Handling Advice:
Protect from light and moisture.
Hazards:
H315 - H319 - H335
InChi:
InChI=1S/C17H17NO3/c1-2-3-4-9-20-13-6-8-15-17(11-13)21-16-10-12(19)5-7-14(16)18-15/h5-8,10-11H,2-4,9H2,1H3
InChiKey:
ZPSOKQFFOYYPKC-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 87687-03-4. Formula: C17H17NO3. MW: 283.32. Resorufin pentyl ether (7-Pentoxyresorufin) is a fluorogenic substrate used for monitoring cytochrome P450 (CYP450) activities in cell extracts and solutions. It is used as substrate for 7-Pentoxyresorufin-O-dealkylase (PROD) assays. It is used to screen the inhibition/activation potential of test compounds, to predict potential drug-drug interactions, or to monitor other CYP450 activities. Cytochrome P450 oxidase is a large number of evolutionary related oxidative enzymes important in animal, plant, and bacterial physiology. Most cytochromes P450 (CYPs) have about 500 amino acids and a heme group at the active site. Upon enzymatic cleavage of 7-Pentoxyresorufin by CYP450, the fluorescent hydrolysis product resorufin is released and its fluorescence can be used to quantify enzyme activity. Spectral data of Resorufin: lambdaex=571nm, lambdaem=585nm. Resorufin pentyl ether shows also antibacterial properties.
MDL:
MFCD00037664
Molecular Formula:
C17H17NO3
Molecular Weight:
283.32
Package Type:
Vial
Precautions:
P302 + P352 - P305 + P351 + P338
Product Description:
Resorufin pentyl ether (7-Pentoxyresorufin) is a fluorogenic substrate used for monitoring cytochrome P450 (CYP450) activities in cell extracts and solutions. It is used as substrate for 7-Pentoxyresorufin-O-dealkylase (PROD) assays. It is used to screen the inhibition/activation potential of test compounds, to predict potential drug-drug interactions, or to monitor other CYP450 activities. Cytochrome P450 oxidase is a large number of evolutionary related oxidative enzymes important in animal, plant, and bacterial physiology. Most cytochromes P450 (CYPs) have about 500 amino acids and a heme group at the active site. Upon enzymatic cleavage of 7-Pentoxyresorufin by CYP450, the fluorescent hydrolysis product resorufin is released and its fluorescence can be used to quantify enzyme activity. Spectral data of Resorufin: lambdaex=571nm, lambdaem=585nm. Resorufin pentyl ether shows also antibacterial properties.
Purity:
>98% (TLC)
Signal word:
Warning
SMILES:
O=C1C=C2OC3=CC(OCCCCC)=CC=C3N=C2C=C1
Solubility Chemicals:
Soluble in acetonitrile, DMSO or ethanol (all ~1mg/ml).
Source / Host:
Synthetic
Transportation:
Non-hazardous
UNSPSC Number:
41105331
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
(1) R.A. Lubet, et al.; Arch. Biochem. Biophys. 238, 43 (1985) | (2) D. Parma, et al.; Mol. Cell Biochem. 189, 201 (1998) | (3) S. Uehara, et al.; J. Pharmacol. Exp. Ther. 339, 651 (2011) | (4) M.V. Caballero, et al.; Food Chem. Toxicol. 83, 215 (2015) | (5) D.M. Schmitt, et al.; Int. J. Antimircob. Agents 48, 367 (2016) | (6) H. Ozaki, et al.; J. Toxicol. Sci. 41, 551 (2016) | (7) R.O. Juvonen, et al.; ACS Omega 6, 11286 (2021) | (8) S. Uehara, et al.; Drug Metab. Pharmacokinet. 44, 100454 (2022)